Ontology highlight
ABSTRACT: Objectives
Research on the cognitive sequelae of mild traumatic brain injury (mTBI) suggests that, despite generally rapid recovery, difficulties may persist in the domain of cognitive control. The goal of this study was to examine whether individuals with chronic blast-related mTBI show behavioral or neural alterations associated with cognitive control.Methods
We collected event-related functional magnetic resonance imaging (fMRI) data during a flanker task in 17 individuals with blast-related mTBI and 16 individuals with blast-exposure without TBI (control).Results
Groups did not significantly differ in behavioral measures of cognitive control. Relative to the control group, the mTBI group showed greater deactivation of regions associated with the default mode network during the processing of errors. Additionally, error processing in the mTBI group was associated with enhanced negative coupling between the default mode network and the dorsal anterior cingulate cortex as well as the dorsolateral prefrontal cortex, regions of the salience and central executive networks that are associated with cognitive control.Conclusions
These results suggest that deactivation of default mode network regions and associated enhancements of connectivity with cognitive control regions may act as a compensatory mechanism for successful cognitive control task performance in mTBI. (JINS, 2018, 24, 662-672).
SUBMITTER: Sullivan DR
PROVIDER: S-EPMC6108927 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Sullivan Danielle R DR Hayes Jasmeet P JP Lafleche Ginette G Salat David H DH Verfaellie Mieke M
Journal of the International Neuropsychological Society : JINS 20180629 7
<h4>Objectives</h4>Research on the cognitive sequelae of mild traumatic brain injury (mTBI) suggests that, despite generally rapid recovery, difficulties may persist in the domain of cognitive control. The goal of this study was to examine whether individuals with chronic blast-related mTBI show behavioral or neural alterations associated with cognitive control.<h4>Methods</h4>We collected event-related functional magnetic resonance imaging (fMRI) data during a flanker task in 17 individuals wit ...[more]