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Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial.


ABSTRACT: OBJECTIVE:To test the hypothesis that environmental compared with nasal cannula oxygen decreases episodes of intermittent hypoxemia (oxygen saturations <85% for ?10 seconds) in preterm infants on supplemental oxygen by providing a more stable hypopharyngeal oxygen concentration. STUDY DESIGN:This was a single center randomized crossover trial with a 1:1 parallel allocation to order of testing. Preterm infants on supplemental oxygen via oxygen environment maintained by a servo-controlled system or nasal cannula with flow rates??1.0 L per kg per minute were crossed over every 24 hours for 96 hours. Data were collected electronically to capture real time numeric and waveform data from patient monitors. RESULTS:Twenty-five infants with gestational age of 27?±?2 weeks (mean?±?SD) and a birth weight of 933?±?328 g were studied at postnatal day 36?±?26. The number of episodes of intermittent hypoxemia per 24 hours was 117?±?77 (median, 98; range, 4-335) with oxygen environment vs 130?±?63 (median, 136; range, 16-252) with nasal cannula (P?=?.002). Infants on oxygen environment compared with nasal cannula also had decreased episodes of severe intermittent hypoxemia (P?=?.005). Infants on oxygen environment compared with nasal cannula had a lower proportion of time with oxygen saturations?<85% (.05?±?.03 vs .06?±?.03, P?

SUBMITTER: Travers CP 

PROVIDER: S-EPMC6109600 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial.

Travers Colm P CP   Carlo Waldemar A WA   Nakhmani Arie A   Bhatia Shweta S   Gentle Samuel J SJ   Amperayani VenkataNagaSai Apurupa VA   Indic Premananda P   Aban Inmaculada I   Ambalavanan Namasivayam N  

The Journal of pediatrics 20180425


<h4>Objective</h4>To test the hypothesis that environmental compared with nasal cannula oxygen decreases episodes of intermittent hypoxemia (oxygen saturations <85% for ≥10 seconds) in preterm infants on supplemental oxygen by providing a more stable hypopharyngeal oxygen concentration.<h4>Study design</h4>This was a single center randomized crossover trial with a 1:1 parallel allocation to order of testing. Preterm infants on supplemental oxygen via oxygen environment maintained by a servo-cont  ...[more]

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