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Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.


ABSTRACT: Cognitive flexibility is a critical component of executive function and is strongly influenced by genetic factors. We conducted a genome-wide association study of cognitive flexibility (as measured by perseverative errors on the Wisconsin Card Sorting Test) in two sets of African American (AA) and European American (EA) subjects (Yale-Penn-1: 1,411 AAs/949 EAs; Yale-Penn-2: 1,178 AAs/1,335 EAs). We examined the association of cognitive flexibility with genotyped or imputed SNPs across the genome. In AAs, two correlated common single nucleotide polymorphisms (SNPs) (rs7165213/rs35633795) in the downstream region of the noncoding gene LOC101927286 on chromosome 15 showed genome-wide significant (GWS) associations with cognitive flexibility (Yale-Penn-1: p?=?6.0 × 10-9 /1.3 × 10-8 ; Yale-Penn-2: p?=?.029/.010; meta-analysis: p?=?4.2 × 10-7 /1.0 × 10-7 ) in the same effect direction. In EAs, no GWS associations were observed. Enriched gene sets identified by Data-driven Expression-Prioritized Integration for Complex Traits (DEPICT) analysis of the top SNPs (pmeta-analysis ?

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6110090 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.

Zhang Huiping H   Zhou Hang H   Lencz Todd T   Farrer Lindsay A LA   Kranzler Henry R HR   Gelernter Joel J  

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20180701 5


Cognitive flexibility is a critical component of executive function and is strongly influenced by genetic factors. We conducted a genome-wide association study of cognitive flexibility (as measured by perseverative errors on the Wisconsin Card Sorting Test) in two sets of African American (AA) and European American (EA) subjects (Yale-Penn-1: 1,411 AAs/949 EAs; Yale-Penn-2: 1,178 AAs/1,335 EAs). We examined the association of cognitive flexibility with genotyped or imputed SNPs across the genome  ...[more]

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