Myocardial Infarction Produces Sustained Proinflammatory Endothelial Activation in Remote Arteries.

ABSTRACT:

Background

In the months after acute myocardial infarction (MI), risk for acute atherothrombotic events in nonculprit arteries increases several fold.

Objectives

This study investigated whether sustained proinflammatory and prothrombotic endothelial alterations occur in remote vessels after MI.

Methods

Wild-type mice, atherosclerotic mice with double knockout (DKO) of the low-density lipoprotein receptor and Apobec-1, and DKO mice treated with the Nox-inhibitor apocynin were studied at baseline and at 3 and 21 days after closed-chest MI. Ultrasound molecular imaging of P-selectin, vascular cell adhesion molecule (VCAM)-1, von Willebrand factor (VWF) A1-domain, and platelet GPIbα was performed. Intravital microscopy was used to characterize post-MI leukocyte and platel

SUBMITTER: Moccetti F 

PROVIDER: S-EPMC6110111 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature