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Exercise capacity and cancer-specific quality of life following curative intent treatment of stage I-IIIA lung cancer.

ABSTRACT: PURPOSE:Lung cancer survivors are at risk for health impairments resulting from the effects and/or treatment of lung cancer and comorbidities. Practical exercise capacity (EC) assessments can help identify impairments that would otherwise remain undetected. In this study, we characterized and analyzed the association between functional EC and cancer-specific quality of life (QoL) in lung cancer survivors who previously completed curative intent treatment. METHODS:In a cross-sectional study of 62 lung cancer survivors who completed treatment ??1 month previously, we assessed functional EC with the 6-min walk distance (6MWD) and cancer-specific QoL with the European Organization for Research and Treatment of Cancer QoL Questionnaire Core 30 (EORTC-QLQ-C30). Cancer-specific QoL was defined using a validated composite EORTC-QLQ-C30 summary score. Univariable (UVA) and multivariable linear regression analyses (MVA) were performed to assess the relationship between functional EC and cancer-specific QoL. RESULTS:Lung cancer survivors had reduced functional EC (mean 6MWD?=?335 m, 65% predicted) and QoL (mean EORTC-QLQ-C30 summary score?=?77, scale range 0-100). In UVA, 6MWD was significantly associated with cancer-specific QoL (R2?=?0.16, p?=?0.001). In MVA, in a final model that also included heart failure, obstructive sleep apnea, and psychiatric illness, 6MWD was independently associated with cancer-specific QoL (partial R2?=?0.20, p?=?0.001). CONCLUSIONS:Functional EC was independently associated with cancer-specific QoL in lung cancer patients postcurative intent treatment. Exercise-based interventions aimed at improving EC may improve cancer-specific QoL in these patients.

SUBMITTER: Ha D

PROVIDER: S-EPMC6110278 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Exercise capacity and cancer-specific quality of life following curative intent treatment of stage I-IIIA lung cancer.

Ha Duc D Ries Andrew L AL Mazzone Peter J PJ Lippman Scott M SM Fuster Mark M MM

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20180210 7

<h4>Purpose</h4>Lung cancer survivors are at risk for health impairments resulting from the effects and/or treatment of lung cancer and comorbidities. Practical exercise capacity (EC) assessments can help identify impairments that would otherwise remain undetected. In this study, we characterized and analyzed the association between functional EC and cancer-specific quality of life (QoL) in lung cancer survivors who previously completed curative intent treatment.<h4>Methods</h4>In a cross-sectio ...[more]

PMID: 29429006

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Project description:ObjectivesTo inform personalised home-based rehabilitation interventions, we sought to gain in-depth understanding of lung cancer survivors' (1) attitudes and perceived self-efficacy towards telemedicine; (2) knowledge of the benefits of rehabilitation and exercise training; (3) perceived facilitators and preferences for telerehabilitation; and (4) health goals following curative intent therapy.DesignWe conducted semi-structured interviews guided by Bandura's Social Cognitive Theory and used directed content analysis to identify salient themes.SettingOne USA Veterans Affairs Medical Center.ParticipantsWe enrolled 20 stage I-IIIA lung cancer survivors who completed curative intent therapy in the prior 1-6 months. Eighty-five percent of participants had prior experience with telemedicine, but none with telerehabilitation or rehabilitation for lung cancer.ResultsParticipants viewed telemedicine as convenient, however impersonal and technologically challenging, with most reporting low self-efficacy in their ability to use technology. Most reported little to no knowledge of the potential benefits of specific exercise training regimens, including those directed towards reducing dyspnoea, fatigue or falls. If they were to design their own telerehabilitation programme, participants had a predominant preference for live and one-on-one interaction with a therapist, to enhance therapeutic relationship and ensure correct learning of the training techniques. Most participants had trouble stating their explicit health goals, with many having questions or concerns about their lung cancer status. Some wanted better control of symptoms and functional challenges or engage in healthful behaviours.ConclusionsFeatures of telerehabilitation interventions for lung cancer survivors following curative intent therapy may need to include strategies to improve self-efficacy and skills with telemedicine. Education to improve knowledge of the benefits of rehabilitation and exercise training, with alignment to patient-formulated goals, may increase uptake. Exercise training with live and one-on-one therapist interaction may enhance learning, adherence, and completion. Future work should determine how to incorporate these features into telerehabilitation.

Dataset Information

Exercise capacity and cancer-specific quality of life following curative intent treatment of stage I-IIIA lung cancer.

Publications

Exercise capacity and cancer-specific quality of life following curative intent treatment of stage I-IIIA lung cancer.

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