Ontology highlight
ABSTRACT:
SUBMITTER: Araujo ARD
PROVIDER: S-EPMC6110467 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Araújo Ana Rita D ARD Melo Tânia T Maciel Elisabete A EA Pereira Clara C Morais Catarina M CM Santinha Deolinda R DR Tavares Joana F JF Oliveira Helena H Jurado Amália S AS Costa Vítor V Domingues Pedro P Domingues Maria Rosário M MRM Santos Manuel A S MAS
PloS one 20180827 8
The occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10-4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and deregulates genes related to lipid metabolism, but there is no experimental proof that such errors alter yeast lipid profiles. We engineered yeast strains to misincorporate serine at alanine and glycine sites on a global scale and evaluated the putative ...[more]