Ontology highlight
ABSTRACT:
SUBMITTER: Mure F
PROVIDER: S-EPMC6110769 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Mure Fabrice F Corbin Antoine A Benbahouche Nour El Houda NEH Bertrand Edouard E Manet Evelyne E Gruffat Henri H
Scientific reports 20180827 1
The RNA exosome fulfills important functions in the processing and degradation of numerous RNAs species. However, the mechanisms of recruitment to its various nuclear substrates are poorly understood. Using Epstein-Barr virus mRNAs as a model, we have discovered a novel function for the splicing factor SRSF3 in the quality control of nuclear mRNAs. We have found that viral mRNAs generated from intronless genes are particularly unstable due to their degradation by the nuclear RNA exosome. This ef ...[more]