Ontology highlight
ABSTRACT:
SUBMITTER: Vlachogiannis G
PROVIDER: S-EPMC6112415 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180201 6378
Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear. We report on a living biobank of PDOs from metastatic, heavily pretreated colorectal and gastroesophageal cancer patients recruited in phase 1/2 clinical trials. Phenotypic and genotypic profiling of PDOs showed a high degree of similarity to the original patient tumors. Molecular profiling of tumor organoids was matched to d ...[more]