Ontology highlight
ABSTRACT:
SUBMITTER: Shao C
PROVIDER: S-EPMC6113207 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Shao Changjuan C Qiu Yangyang Y Liu Juan J Feng Huan H Shen Suqin S Saiyin Hexige H Yu Wenbo W Wei Youheng Y Yu Long L Su Wei W Wu Jiaxue J
Cell death & disease 20180828 9
PARP12 is a mono-ADP-ribosyltransferase, but its function remains largely unknown. Here, we identified four-and-a-half LIM-only protein 2 (FHL2) as a functional partner of PARP12 through protein affinity purification. Although PARP12 did not mono-ADP-ribosylate FHL2 in vitro and in vivo, PARP12 deficiency decreased the protein level of FHL2 by promoting its ubiquitination and increased the expression level of transforming growth factor beta1 (TGF-β1), which is independent of PARP12 enzymatic act ...[more]