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Computational characterization and identification of human polycystic ovary syndrome genes.

ABSTRACT: Human polycystic ovary syndrome (PCOS) is a highly heritable disease regulated by genetic and environmental factors. Identifying PCOS genes is time consuming and costly in wet-lab. Developing an algorithm to predict PCOS candidates will be helpful. In this study, for the first time, we systematically analyzed properties of human PCOS genes. Compared with genes not yet known to be involved in PCOS regulation, known PCOS genes display distinguishing characteristics: (i) they tend to be located at network center; (ii) they tend to interact with each other; (iii) they tend to enrich in certain biological processes. Based on these features, we developed a machine-learning algorithm to predict new PCOS genes. 233 PCOS candidates were predicted with a posterior probability >0.9. Evidence supporting 7 of the top 10 predictions has been found.

SUBMITTER: Zhang XZ

PROVIDER: S-EPMC6113217 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Computational characterization and identification of human polycystic ovary syndrome genes.

Zhang Xing-Zhong XZ Pang Yan-Li YL Wang Xian X Li Yan-Hui YH

Scientific reports 20180828 1

Human polycystic ovary syndrome (PCOS) is a highly heritable disease regulated by genetic and environmental factors. Identifying PCOS genes is time consuming and costly in wet-lab. Developing an algorithm to predict PCOS candidates will be helpful. In this study, for the first time, we systematically analyzed properties of human PCOS genes. Compared with genes not yet known to be involved in PCOS regulation, known PCOS genes display distinguishing characteristics: (i) they tend to be located at ...[more]

PMID: 30154492

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