Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress.
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ABSTRACT:
SUBMITTER: Lam M
PROVIDER: S-EPMC6113221 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress.
Lam Mable M Lawrence David A DA Ashkenazi Avi A Walter Peter P
Cell death and differentiation 20180710 8
Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activation upon ER stress. ...[more]
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