Ontology highlight
ABSTRACT:
SUBMITTER: Jeong E
PROVIDER: S-EPMC6113229 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Jeong Eutteum E Choi Han Kyoung HK Park Jin Hee JH Lee Soo Young SY
Cell death and differentiation 20180118 8
The receptor activator of nuclear factor-κB (RANK) protein activates various protein kinase signaling cascades, including those involving NF-κB, mitogen-activated protein kinase (MAPK), and Bruton tyrosine kinase (Btk)/tyrosine-protein kinase Tec. However, the mechanism underlying the negative regulation of RANK by downstream signaling molecules remains unclear. Here, we report that Src homology 3 domain and cysteine-rich domain-containing protein 2 (STAC2) is a novel RANK ligand-inducible prote ...[more]