Ontology highlight
ABSTRACT:
SUBMITTER: Chang R
PROVIDER: S-EPMC6113304 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Chang Renxu R Song Lele L Xu Yi Y Wu Yanjun Y Dai Cheng C Wang Xinyu X Sun Xia X Hou Yingyong Y Li Wei W Zhan Xianbao X Zhan Lixing L
Nature communications 20180828 1
Loss of WW domain-containing oxidoreductase (Wwox) expression has been observed in breast cancer (BC). However, its regulatory effects are largely unknown, especially in triple-negative breast cancer (TNBC). Herein, gene expression profiling revealed that JAK/STAT3 pathway was one of the most differentially modulated pathways in basal-like BC cells. The lower expression of Wwox was significantly correlated with high activation of STAT3 in basal-like cells and TNBC tissues. Overexpression of Wwox ...[more]