Ontology highlight
ABSTRACT:
SUBMITTER: Jonsson MKB
PROVIDER: S-EPMC6113540 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Jonsson Malin K B MKB Hartman Robin J G RJG Ackers-Johnson Matthew M Tan Wilson L W WLW Lim Bing B van Veen Toon A B TAB Foo Roger S RS
JACC. Basic to translational science 20161130 7
Cardiovascular disease remains the number one global cause of death and presents as multiple phenotypes in which the interplay between cardiomyocytes and cardiac fibroblasts (CFs) has become increasingly highlighted. Fetal and adult CFs influence neighboring cardiomyocytes in different ways. Thus far, a detailed comparison between the two is lacking. Using a genome-wide approach, we identified and validated 2 crucial players for maintaining the adult primary human CF phenotype. Knockdown of thes ...[more]