Ticagrelor Removal From Human Blood.
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ABSTRACT:
SUBMITTER: Angheloiu GO
PROVIDER: S-EPMC6113557 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Ticagrelor Removal From Human Blood.
Angheloiu George O GO Gugiu Gabriel B GB Ruse Cristian C Pandey Rishikesh R Dasari Ramachandra R RR Whatling Carl C
JACC. Basic to translational science 20170424 2
The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole bloo ...[more]
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