Ontology highlight
ABSTRACT:
SUBMITTER: Thackray AM
PROVIDER: S-EPMC6113635 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Thackray Alana M AM Andréoletti Olivier O Bujdoso Raymond R
Brain : a journal of neurology 20180901 9
Mammalian prions propagate by template-directed misfolding and aggregation of normal cellular prion related protein PrPC as it converts into disease-associated conformers collectively referred to as PrPSc. Mammalian species may be permissive for prion disease because these hosts have co-evolved specific co-factors that assist PrPC conformational change and prion propagation. We have tested this hypothesis by examining whether faithful prion propagation occurs in the normally PrPC-null invertebra ...[more]