Ontology highlight
ABSTRACT:
SUBMITTER: Kessler T
PROVIDER: S-EPMC6113655 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Kessler Torsten T Baumeier Ariane A Brand Caroline C Grau Michael M Angenendt Linus L Harrach Saliha S Stalmann Ursula U Schmidt Lars Henning LH Gosheger Georg G Hardes Jendrik J Andreou Dimosthenis D Dreischalück Johannes J Lenz Georg G Wardelmann Eva E Mesters Rolf M RM Schwöppe Christian C Berdel Wolfgang E WE Hartmann Wolfgang W Schliemann Christoph C
Translational oncology 20180817 6
Aminopeptidase N (CD13) is expressed on tumor vasculature and tumor cells. It represents a candidate for targeted therapy, e.g., by truncated tissue factor (tTF)-NGR, binding to CD13, and causing tumor vascular thrombosis. We analyzed CD13 expression by immunohistochemistry in 97 patients with STS who were treated by wide resection and uniform chemo-radio-chemotherapy. Using a semiquantitative score with four intensity levels, CD13 was expressed by tumor vasculature, or tumor cells, or both (com ...[more]