Ontology highlight
ABSTRACT:
SUBMITTER: Izquierdo HM
PROVIDER: S-EPMC6113928 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Izquierdo Helena M HM Brandi Paola P Gómez Manuel-José MJ Conde-Garrosa Ruth R Priego Elena E Enamorado Michel M Martínez-Cano Sarai S Sánchez Iria I Conejero Laura L Jimenez-Carretero Daniel D Martín-Puig Silvia S Guilliams Martin M Sancho David D
Cell reports 20180801 7
The rapid transit from hypoxia to normoxia in the lung that follows the first breath in newborn mice coincides with alveolar macrophage (AM) differentiation. However, whether sensing of oxygen affects AM maturation and function has not been previously explored. We have generated mice whose AMs show a deficient ability to sense oxygen after birth by deleting Vhl, a negative regulator of HIF transcription factors, in the CD11c compartment (CD11cΔVhl mice). VHL-deficient AMs show an immature-like p ...[more]