Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Sanchez R
PROVIDER: S-EPMC6114101 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sánchez-Sánchez Roberto R Ferre Ignacio I Re Michela M Vázquez Patricia P Ferrer Luis Miguel LM Blanco-Murcia Javier J Regidor-Cerrillo Javier J Pizarro Díaz Manuel M González-Huecas Marta M Tabanera Enrique E García-Lunar Paula P Benavides Julio J Castaño Pablo P Hemphill Andrew A Hulverson Matthew A MA Whitman Grant R GR Rivas Kasey L KL Choi Ryan R Ojo Kayode K KK Barrett Lynn K LK Van Voorhis Wesley C WC Ortega-Mora Luis Miguel LM
International journal for parasitology. Drugs and drug resistance 20180302 1
Neospora caninum is one of the main causes of abortion in cattle, and recent studies have highlighted its relevance as an abortifacient in small ruminants. Vaccines or drugs for the control of neosporosis are lacking. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against several apicomplexan parasites in vitro and in laboratory animal models. We here present the pharmacokinetics, safety and ...[more]