Ontology highlight
ABSTRACT:
SUBMITTER: David M
PROVIDER: S-EPMC6114108 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
David Marion M Lebrun Chantal C Duguet Thomas T Talmont Franck F Beech Robin R Orlowski Stéphane S André François F Prichard Roger K RK Lespine Anne A
International journal for parasitology. Drugs and drug resistance 20180215 1
Haemonchus contortus, one of the most economically important parasites of small ruminants, has become resistant to the anthelmintic ivermectin. Deciphering the role of P-glycoproteins in ivermectin resistance is desirable for understanding and overcoming this resistance. In the model nematode, Caenorhabditis elegans, P-glycoprotein-13 is expressed in the amphids, important neuronal structures for ivermectin activity. We have focused on its ortholog in the parasite, Hco-Pgp-13. A 3D model of Hco- ...[more]