A variant in KCNQ1 gene predicts metabolic syndrome among northern urban Han Chinese women.

ABSTRACT:

Background

Previous studies have reported that the potassium voltage-gated channel subfamily Q member 1 (KCNQ1) gene is associated with diabetes in both European and Asian population. This study aims to find a predictable single nucleotide polymorphism (SNP) to predict the risk of metabolic syndrome (MetS) through investigating the association of SNP in KCNQ1 gene with MetS in Han Chinese women of northern urban area.

Methods

Six SNPs were selected and genotyped in 1381 unrelated women aged 21 and above, who have had physical check-up in Shandong Provincial Qianfoshan Hospital. Cox proportional model was conducted to access the association between SNPs and MetS.

Results

Sixty one women developed MetS between 2010 and 2015 during the 3055 person-year of follow-up. The

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6114251 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature