Ontology highlight
ABSTRACT:
SUBMITTER: Redford L
PROVIDER: S-EPMC6114912 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Redford Lisa L Alhilal Ghanim G Needham Stephanie S O'Brien Ottie O Coaker Julie J Tyson John J Amorim Leonardo Maldaner LM Middleton Iona I Izuogu Osagi O Arends Mark M Oniscu Anca A Alonso Ángel Miguel ÁM Laguna Sira Moreno SM Gallon Richard R Sheth Harsh H Santibanez-Koref Mauro M Jackson Michael S MS Burn John J
PloS one 20180829 8
Somatic mutations in mononucleotide repeats are commonly used to assess the mismatch repair status of tumours. Current tests focus on repeats with a length above 15bp, which tend to be somatically more unstable than shorter ones. These longer repeats also have a substantially higher PCR error rate, and tests that use capillary electrophoresis for fragment size analysis often require expert interpretation. In this communication, we present a panel of 17 short repeats (length 7-12bp) for sequence- ...[more]