Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6115016 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Wang Xue X Dong Baijun B Zhang Kai K Ji Zhongzhong Z Cheng Chaping C Zhao Huifang H Sheng Yaru Y Li Xiaoxia X Fan Liancheng L Xue Wei W Gao Wei-Qiang WQ Zhu Helen He HH
PLoS genetics 20180817 8
Cell polarity and correct mitotic spindle positioning are essential for the maintenance of a proper prostate epithelial architecture, and disruption of the two biological features occurs at early stages in prostate tumorigenesis. However, whether and how these two epithelial attributes are connected in vivo is largely unknown. We herein report that conditional genetic deletion of E-cadherin, a key component of adherens junctions, in a mouse model results in loss of prostate luminal cell polarity ...[more]