Ontology highlight
ABSTRACT:
SUBMITTER: Poschet JF
PROVIDER: S-EPMC61151 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Poschet J F JF Boucher J C JC Tatterson L L Skidmore J J Van Dyke R W RW Deretic V V
Proceedings of the National Academy of Sciences of the United States of America 20011101 24
The CFTR gene encodes a transmembrane conductance regulator, which is dysfunctional in patients with cystic fibrosis (CF). The mechanism by which defective CFTR (CF transmembrane conductance regulator) leads to undersialylation of plasma membrane glycoconjugates, which in turn promote lung pathology and colonization with Pseudomonas aeruginosa causing lethal bacterial infections in CF, is not known. Here we show by ratiometric imaging with lumenally exposed pH-sensitive green fluorescent protein ...[more]