Spatial and temporal analysis of PCP protein dynamics during neural tube closure.
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ABSTRACT:
SUBMITTER: Butler MT
PROVIDER: S-EPMC6115189 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Spatial and temporal analysis of PCP protein dynamics during neural tube closure.
Butler Mitchell T MT Wallingford John B JB
eLife 20180806
Planar cell polarity (PCP) controls convergent extension and axis elongation in all vertebrates. Although asymmetric localization of PCP proteins is central to their function, we understand little about PCP protein localization during convergent extension. Here, we use quantitative live imaging to simultaneously monitor cell intercalation behaviors and PCP protein dynamics in the <i>Xenopus laevis</i> neural plate epithelium. We observed asymmetric enrichment of PCP proteins, but more interestin ...[more]
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