Ontology highlight
ABSTRACT:
SUBMITTER: Gallo C
PROVIDER: S-EPMC6115386 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Gallo Cristina C Fragliasso Valentina V Donati Benedetta B Torricelli Federica F Tameni Annalisa A Piana Simonetta S Ciarrocchi Alessia A
Cell death & disease 20180829 9
Aberrant re-activation of transcription factors occurs frequently in cancer. Recently, we found the basic helix-loop-helix transcription factors DEC1 and DEC2 significantly up-regulated in a model of highly aggressive thyroid cancer, raising the hypothesis that these factors might be part of the program driving progression of these tumors. Here, we investigated for the first time the function of DEC1 and DEC2 in thyroid cancer. Using both gain- and loss-of-function approaches, we showed that DEC ...[more]