Ontology highlight
ABSTRACT:
SUBMITTER: Soderquist RS
PROVIDER: S-EPMC6115427 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Soderquist Ryan S RS Crawford Lorin L Liu Esther E Lu Min M Agarwal Anika A Anderson Gray R GR Lin Kevin H KH Winter Peter S PS Cakir Merve M Wood Kris C KC
Nature communications 20180829 1
While inhibitors of BCL-2 family proteins (BH3 mimetics) have shown promise as anti-cancer agents, the various dependencies or co-dependencies of diverse cancers on BCL-2 genes remain poorly understood. Here we develop a drug screening approach to define the sensitivity of cancer cells from ten tissue types to all possible combinations of selective BCL-2, BCL-X<sub>L</sub>, and MCL-1 inhibitors and discover that most cell lines depend on at least one combination for survival. We demonstrate that ...[more]