Ontology highlight
ABSTRACT:
SUBMITTER: Nathoo AN
PROVIDER: S-EPMC61156 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Nathoo A N AN Moeller R A RA Westlund B A BA Hart A C AC
Proceedings of the National Academy of Sciences of the United States of America 20011101 24
Neuropeptides play critical roles in synaptic signaling in all nervous systems. Unlike classical neurotransmitters, peptidergic neurotransmitters are encoded as preproproteins that are posttranslationally processed to yield bioactive neuropeptides. To identify novel peptidergic neurotransmitters, the Caenorhabditis elegans genome was searched for predicted proteins with the structural hallmarks of neuropeptide preproproteins. Thirty-two C. elegans neuropeptide-like protein (nlp) genes were ident ...[more]