Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6115647 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models.
Wang Yihui Y Chen Biyi B Huang Chun-Kai CK Guo Ang A Wu Jennifer J Zhang Xiaoming X Chen Rong R Chen Cheng C Kutschke William W Weiss Robert M RM Boudreau Ryan L RL Margulies Kenneth B KB Hong Jiang J Song Long-Sheng LS
JACC. Basic to translational science 20180828 4
Heart failure remains a major cause of morbidity and mortality in developed countries. There is still a strong need to devise new mechanism-based treatments for heart failure. Numerous studies have suggested the importance of the Ca<sup>2+</sup>-dependent protease calpain in cardiac physiology and pathology. However, no drugs are currently under development or testing in human patients to target calpain for heart failure treatment. Herein the data demonstrate that inhibition of calpain activity ...[more]
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