Ontology highlight
ABSTRACT:
SUBMITTER: Kamburova EG
PROVIDER: S-EPMC6115667 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kamburova Elena G EG Wisse Bram W BW Joosten Irma I Allebes Wil A WA van der Meer Arnold A Hilbrands Luuk B LB Baas Marije C MC Spierings Eric E Hack Cornelis E CE van Reekum Franka E FE van Zuilen Arjan D AD Verhaar Marianne C MC Bots Michiel L ML Drop Adriaan C A D ACAD Plaisier Loes L Seelen Marc A J MAJ Sanders Jan Stephan JS Hepkema Bouke G BG Lambeck Annechien J A AJA Bungener Laura B LB Roozendaal Caroline C Tilanus Marcel G J MGJ Voorter Christina E CE Wieten Lotte L van Duijnhoven Elly M EM Gelens Mariëlle A C J MACJ Christiaans Maarten H L MHL van Ittersum Frans J FJ Nurmohamed Shaikh A SA Lardy Neubury M NM Swelsen Wendy W van der Pant Karlijn A M I KAMI van der Weerd Neelke C NC Ten Berge Ineke J M IJM Bemelman Frederike J FJ Hoitsma Andries J AJ van der Boog Paul J M PJM de Fijter Johan W JW Betjes Michiel G H MGH Heidt Sebastiaan S Roelen Dave L DL Claas Frans H FH Otten Henny G HG
Journal of the American Society of Nephrology : JASN 20180726 9
<b>Background</b> Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this SAB-based technique may provide a valuable tool in the pretransplant risk stratification of kidney transplant recipients.<b>Methods</b> Previously, we established that pretransplant ...[more]