Toxicity and Pharmacokinetic Studies of Lidocaine and Its Active Metabolite, Monoethylglycinexylidide, in Goat Kids.
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ABSTRACT:
SUBMITTER: Venkatachalam D
PROVIDER: S-EPMC6115778 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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Toxicity and Pharmacokinetic Studies of Lidocaine and Its Active Metabolite, Monoethylglycinexylidide, in Goat Kids.
Venkatachalam Dinakaran D Chambers Paul P Kongara Kavitha K Singh Preet P
Animals : an open access journal from MDPI 20180820 8
This study determined the convulsant plasma concentrations and pharmacokinetic parameters following cornual nerve block and compared the results to recommend a safe dose of lidocaine hydrochloride for goat kids. The plasma concentrations of lidocaine and monoethylglycinexylidide (MGX) were quantified using liquid chromatography-mass spectrometry. A total dose of 7 mg/kg body weight (BW) was tolerated and should therefore be safe for local and regional anesthesia in goat kids. The mean plasma con ...[more]
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