Dataset Information

Dairy Intake and Acne Vulgaris: A Systematic Review and Meta-Analysis of 78,529 Children, Adolescents, and Young Adults.

ABSTRACT: A meta-analysis can help inform the debate about the epidemiological evidence on dairy intake and development of acne. A systematic literature search of PubMed from inception to 11 December 2017 was performed to estimate the association of dairy intake and acne in children, adolescents, and young adults in observational studies. We estimated the pooled random effects odds ratio (OR) (95% CI), heterogeneity (I²-statistics, Q-statistics), and publication bias. We included 14 studies (n = 78,529; 23,046 acne-cases/55,483 controls) aged 7?30 years. ORs for acne were 1.25 (95% CI: 1.15?1.36; p = 6.13 × 10^-8) for any dairy, 1.22 (1.08?1.38; p = 1.62 × 10^-3) for full-fat dairy, 1.28 (1.13?1.44; p = 8.23 × 10^-5) for any milk, 1.22 (1.06?1.41; p = 6.66 × 10^-3) for whole milk, 1.32 (1.16?1.52; p = 4.33 × 10^-5) for low-fat/skim milk, 1.22 (1.00?1.50; p = 5.21 × 10^-2) for cheese, and 1.36 (1.05?1.77; p = 2.21 × 10^-2) for yogurt compared to no intake. ORs per frequency of any milk intake were 1.24 (0.95?1.62) by 2?6 glasses per week, 1.41 (1.05?1.90) by 1 glass per day, and 1.43 (1.09?1.88) by ?2 glasses per day compared to intake less than weekly. Adjusted results were attenuated and compared unadjusted. There was publication bias (p = 4.71 × 10^-3), and heterogeneity in the meta-analyses were explained by dairy and study characteristics. In conclusion, any dairy, such as milk, yogurt, and cheese, was associated with an increased OR for acne in individuals aged 7?30 years. However, results should be interpreted with caution due to heterogeneity and bias across studies.

SUBMITTER: Juhl CR

PROVIDER: S-EPMC6115795 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Dairy Intake and Acne Vulgaris: A Systematic Review and Meta-Analysis of 78,529 Children, Adolescents, and Young Adults.

Juhl Christian R CR Bergholdt Helle K M HKM Miller Iben M IM Jemec Gregor B E GBE Kanters Jørgen K JK Ellervik Christina C

Nutrients 20180809 8

A meta-analysis can help inform the debate about the epidemiological evidence on dairy intake and development of acne. A systematic literature search of PubMed from inception to 11 December 2017 was performed to estimate the association of dairy intake and acne in children, adolescents, and young adults in observational studies. We estimated the pooled random effects odds ratio (OR) (95% CI), heterogeneity (<i>I</i>²-statistics, <i>Q</i>-statistics), and publication bias. We included 14 studies ...[more]

PMID: 30096883

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Project description:BackgroundBrain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris. The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris.MethodsIn this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and depressive symptoms such as nine-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were evaluated with multivariate logistic regression analysis.ResultsOur results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P < 0.05). There was a negative correlation between levels of BDNF and the PHQ-9 scores (r = - 0.486, P < 0.001). Furthermore, acne vulgaris patients with depression showed lower serum BDNF levels (10.96 ± 2.12 ng/ml) compared with acne vulgaris patients without depression (13.85 ± 2.47 ng/ml), as well as with healthy control (14.35 ± 2.70 ng/mg; both P < 0.05). No difference was found in serum BDNF levels between healthy control and acne vulgaris patients without depressive symptoms (z = 0.964, P > 0.05). Similarly, the overall area under the curve of receiver operating characteristic was 0.82, indicating the highly conserving of serum BDNF levels as an biomarker for screening of depression in young adults with acne vulgaris (72% sensitivity and 85% specificity).ConclusionSerum BDNF levels were decreased and negatively associated with depressive symptoms in young Chinese adults with acne vulgaris.

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Dataset Information

Dairy Intake and Acne Vulgaris: A Systematic Review and Meta-Analysis of 78,529 Children, Adolescents, and Young Adults.

Publications

Dairy Intake and Acne Vulgaris: A Systematic Review and Meta-Analysis of 78,529 Children, Adolescents, and Young Adults.

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