Dataset Information

Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort.

ABSTRACT: No studies showing that food consumption is a modifier of the association of variants of the leptin receptor gene (LEPR) with body weight have involved a Brazilian population. The aim of this study was to evaluate the modifying effect of dietary intake on the association between the LEPR gene and excess weight. In this study, 1211 children and adolescents aged 4?11 years were assessed. Participants were genotyped for 112 single-nucleotide variants of the LEPR gene. Anthropometric measurements were performed, and dietary data were obtained. Logistic regressions were used to study the associations of interest. Of the participants, 13.4% were overweight/obese. The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median (odds ratio OR = 1.92; 95% confidence interval CI = 1.18?3.14), with daily frequency of consumption of drink/artificial juice (OR = 2.15; 95% CI = 1.26?3.68) and refined cereals (OR = 2.17; 95% CI = 1.31?3.62) above the median. The risk allele (G) of variant rs1177681 was also associated with excess weight (OR = 2.74; 95% CI = 1.65?4.57) in subjects with a daily frequency of refined cereal consumption above the median. The association between LEPR and excess weight can be modulated by the type and distribution of dietary fatty acids, sugary drinks, and refined cereals.

SUBMITTER: Dos Santos Rocha A

PROVIDER: S-EPMC6116060 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort.

Dos Santos Rocha Aline A de Cássia Ribeiro-Silva Rita R Nunes de Oliveira Costa Gustavo G Alexandrina Figueiredo Camila C Cunha Rodrigues Laura L Maria Alvim Matos Sheila S Leovigildo Fiaccone Rosemeire R Oliveira Pablo Rafael PR Alves-Santos Nadya Helena NH Blanton Ronald E RE Lima Barreto Maurício M

Nutrients 20180818 8

No studies showing that food consumption is a modifier of the association of variants of the leptin receptor gene (LEPR) with body weight have involved a Brazilian population. The aim of this study was to evaluate the modifying effect of dietary intake on the association between the LEPR gene and excess weight. In this study, 1211 children and adolescents aged 4⁻11 years were assessed. Participants were genotyped for 112 single-nucleotide variants of the LEPR gene. Anthropom ...[more]

PMID: 30126176

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Dataset Information

Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort.

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Food Consumption as a Modifier of the Association between <i>LEPR</i> Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort.

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