Multimodal Radiomic Features for the Predicting Gleason Score of Prostate Cancer.

ABSTRACT:

Background

Novel radiomic features are enabling the extraction of biological data from routine sequences of MRI images. This study's purpose was to establish a new model, based on the joint intensity matrix (JIM), to predict the Gleason score (GS) of prostate cancer (PCa) patients.

Methods

A retrospective dataset comprised of the diagnostic imaging data of 99 PCa patients was used, extracted from The Cancer Imaging Archive's (TCIA) T2-Weighted (T2-WI) and apparent diffusion coefficient (ADC) images. Radiomic features derived from JIM and the grey level co-occurrence matrix (GLCM) were extracted from the reported tumor locations. The Kruskal-Wallis test and Spearman's rank correlation identified features related to the GS. The Random Forest classifier model was implemented to identify the best performing signature of JIM and GLCM radiomic features to predict for GS.

Results

Five JIM-derived features: contrast, homogeneity, difference variance, dissimilarity, and inverse difference were independent predictors of GS (p < 0.05). Combined JIM and GLCM analysis provided the best performing area-under-the-curve, with values of 78.40% for GS ? 6, 82.35% for GS = 3 + 4, and 64.76% for GS ? 4 + 3.

Conclusion

This retrospective study produced a novel predictive model for GS by the incorporation of JIM data from standard diagnostic MRI images.

SUBMITTER: Chaddad A 

PROVIDER: S-EPMC6116195 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature