Dataset Information

Using microRNAs as Novel Predictors of Urologic Cancer Survival: An Integrated Analysis.

ABSTRACT:

Background

MicroRNAs(miRNAs) are involved in the formation, maintenance, and metastasis of urologic cancer. Here, we aim to gather and evaluate all of the evidence regarding the potential role of miRNAs as novel predictors of urologic cancer survival.

Methods

A systematic review was performed to identify and score all of the published studies that evaluated the prognostic effects of miRNAs in kidney (KCa), bladder (BCa) or prostate cancer (PCa). Where appropriate, the summary effects of miRNAs on urologic cancer were meta-analysed. The reliability of those results was then further validated by an integrated analysis of the TCGA cohort and miRNA panel.

Results

Of 151 datasets, 80 miRNAs were enrolled in this systematic review. A meta-analysis of the prognostic qualities of each miRNA identified an objective association between miRNA and prognosis. miR-21 was identified as an unfavourable miRNA with the overall survival (HR:2.699, 1.76-4.14, P?ConclusionsA miRNA panel may be able to determine the prognosis of urologic tumour more effectively and compensate for the unreliability of individual miRNA in estimating prognosis. More large-scale studies are therefore required to evaluate the unbiased prognostic value of miRNAs in urologic cancer effectively.

SUBMITTER: Chen Z

PROVIDER: S-EPMC6116416 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Publications

Using microRNAs as Novel Predictors of Urologic Cancer Survival: An Integrated Analysis.

Chen Zhicong Z Zhan Yonghao Y Chi Jieshan J Guo Shuyuan S Zhong Xinliang X He Anbang A Zheng Jianrong J Gong Yanqing Y Li Xuesong X Zhou Liqun L

EBioMedicine 20180721

<h4>Background</h4>MicroRNAs(miRNAs) are involved in the formation, maintenance, and metastasis of urologic cancer. Here, we aim to gather and evaluate all of the evidence regarding the potential role of miRNAs as novel predictors of urologic cancer survival.<h4>Methods</h4>A systematic review was performed to identify and score all of the published studies that evaluated the prognostic effects of miRNAs in kidney (KCa), bladder (BCa) or prostate cancer (PCa). Where appropriate, the summary effe ...[more]

PMID: 30037718

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Dataset Information

Using microRNAs as Novel Predictors of Urologic Cancer Survival: An Integrated Analysis.

Background

Methods

Results

Publications

Using microRNAs as Novel Predictors of Urologic Cancer Survival: An Integrated Analysis.

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