Ontology highlight
ABSTRACT:
SUBMITTER: Park M
PROVIDER: S-EPMC6116783 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Park Misun M Steinberg Susan F SF
JACC. Basic to translational science 20180828 4
The mechanism that leads to a decrease in β<sub>1</sub>-adrenergic receptor (β<sub>1</sub>AR) expression in the failing heart remains uncertain. This study shows that cardiomyocyte β<sub>1</sub>AR expression and isoproterenol responsiveness decrease in response to oxidative stress. Studies of mechanisms show that the redox-dependent decrease in β<sub>1</sub>AR expression is uniquely prevented by carvedilol and not other βAR ligands. Carvedilol also promotes the accumulation of N-terminally trunc ...[more]