Ontology highlight
ABSTRACT:
SUBMITTER: Wintermantel TM
PROVIDER: S-EPMC6116893 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Wintermantel Tim M TM Campbell Rebecca E RE Porteous Robert R Bock Dagmar D Gröne Hermann-Josef HJ Todman Martin G MG Korach Kenneth S KS Greiner Erich E Pérez Cristian A CA Schütz Günther G Herbison Allan E AE
Neuron 20061001 2
The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mutant mice. An ERalpha-selective compound was sufficient to generate positive feedback in wild-type mice. As GnRH neurons do not express ERalpha, estrogen positive feedback upon GnRH ...[more]