Ontology highlight
ABSTRACT:
SUBMITTER: Lynn H
PROVIDER: S-EPMC6116948 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Lynn Heather H Sun Xiaoguang X Ayshiev Djanybek D Siegler Jessica H JH Rizzo Alicia N AN Karnes Jason H JH Gonzales Garay Manuel M Wang Ting T Casanova Nancy N Camp Sara M SM Ellis Nathan A NA Garcia Joe G N JGN
PloS one 20180830 8
<h4>Introduction</h4>Pseudogenes are paralogues of functional genes historically viewed as defunct due to either the lack of regulatory elements or the presence of frameshift mutations. Recent evidence, however, suggests that pseudogenes may regulate gene expression, although the functional role of pseudogenes remains largely unknown. We previously reported that MYLKP1, the pseudogene of MYLK that encodes myosin light chain kinase (MLCK), is highly expressed in lung and colon cancer cell lines a ...[more]