Dataset Information

Complementary regional heterogeneity information from COPD patients obtained using oxygen-enhanced MRI and chest CT.

ABSTRACT:

Background

The heterogeneous distribution of emphysema is a key feature of chronic obstructive pulmonary disease (COPD) patients that typically is evaluated using high-resolution chest computed tomography (HRCT). Oxygen-enhanced pulmonary magnetic resonance imaging (OEMRI) is a new method to obtain information regarding regional ventilation, diffusion, and perfusion in the lung without radiation exposure. We aimed to compare OEMRI with HRCT for the assessment of heterogeneity in COPD patients.

Methods

Forty patients with stable COPD underwent quantitative HRCT, OEMRI, and pulmonary function tests, including arterial blood gas analysis. OEMRI was also performed on nine healthy control subjects. We measured the severity of emphysema (percent low attenuation volume; LAV%) in whole lungs and the standard deviations (SDs) of the LAV% values of 10 isovolumetric partitions (SD-LAV) as an index of cranial-caudal heterogeneity. Similarly, relative enhancement ratios of oxygen (RERs) in whole lungs from OEMRI and SD-RER were analyzed.

Results

COPD patients showed a lower mean RER than control subjects (12.6% vs 22.0%, p<0.01). The regional heterogeneity of the RERs was not always consistent with the LAV distribution. Both the HRCT (LAV% and SD-LAV) and the OEMRI (RER and SD-RER) indices were significantly associated with the diffusion capacity (DLCO) and partial pressure of oxygen in arterial blood (PaO2). The PaO2 was associated only with the heterogeneity index of HRCT (SD-LAV) (R2 = 0.39); however, the PaO2 was associated with both the mean RER and heterogeneity (SD-RER) in the multivariate analysis (R2 = 0.38).

Conclusions

OEMRI-derived parameters were directly associated with oxygen uptake in COPD patients. Although the OEMRI-derived parameters were not identical to the HRCT-derived parameters, the cranial-caudal heterogeneity in HRCT or OEMRI was complementary to that in evaluations of oxygen uptake in the lungs. Functional imaging seems to provide new insights into COPD pathophysiology without radiation exposure.

SUBMITTER: Fuseya Y

PROVIDER: S-EPMC6117056 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Complementary regional heterogeneity information from COPD patients obtained using oxygen-enhanced MRI and chest CT.

Fuseya Yoshinori Y Muro Shigeo S Sato Susumu S Tanabe Naoya N Sato Atsuyasu A Tanimura Kazuya K Hasegawa Koichi K Uemasu Kiyoshi K Kubo Takeshi T Kido Aki A Fujimoto Koji K Fushimi Yasutaka Y Kusahara Hiroshi H Sakashita Naotaka N Ohno Yoshiharu Y Togashi Kaori K Mishima Michiaki M Hirai Toyohiro T

PloS one 20180830 8

<h4>Background</h4>The heterogeneous distribution of emphysema is a key feature of chronic obstructive pulmonary disease (COPD) patients that typically is evaluated using high-resolution chest computed tomography (HRCT). Oxygen-enhanced pulmonary magnetic resonance imaging (OEMRI) is a new method to obtain information regarding regional ventilation, diffusion, and perfusion in the lung without radiation exposure. We aimed to compare OEMRI with HRCT for the assessment of heterogeneity in COPD pat ...[more]

PMID: 30161221

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Project description:PURPOSE:To derive lobar ventilation in patients with chronic obstructive pulmonary disease (COPD) using a rapid time-series hyperpolarized xenon-129 (HPX) magnetic resonance imaging (MRI) technique and compare this to ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT), correlating the results with high-resolution computed tomography (CT) and pulmonary function tests (PFTs). MATERIALS AND METHODS:Twelve COPD subjects (GOLD stages I-IV) participated in this study and underwent HPX-MRI, V/Q-SPECT/CT, high-resolution CT, and PFTs. HPX-MRI was performed using a novel time-series spiral k-space sampling approach. Relative percentage ventilations were calculated for individual lobe for comparison to the relative SPECT lobar ventilation and perfusion. The absolute HPX-MRI percentage ventilation in each lobe was compared to the absolute CT percentage emphysema score calculated using a signal threshold method. Pearson's correlation and linear regression tests were performed to compare each imaging modality. RESULTS:Strong correlations were found between the relative lobar percentage ventilation with HPX-MRI and percentage ventilation SPECT (r?=?0.644; p?<?0.001) and percentage perfusion SPECT (r?=?0.767; p?<?0.001). The absolute CT percentage emphysema and HPX percentage ventilation correlation was also statistically significant (r?=?0.695, p?<?0.001). The whole lung HPX percentage ventilation correlated with the PFT measurements (FEV1 with r?=?-?0.886, p?<?0.001*, and FEV1/FVC with r?=?-?0.861, p?<?0.001*) better than the whole lung CT percentage emphysema score (FEV1 with r?=?-?0.635, p?=?0.027; and FEV1/FVC with r?=?-?0.652, p?=?0.021). CONCLUSION:Lobar ventilation with HPX-MRI showed a strong correlation with lobar ventilation and perfusion measurements derived from SPECT/CT, and is better than the emphysema score obtained with high-resolution CT. KEY POINTS:• The ventilation hyperpolarized xenon-129 MRI correlates well with ventilation and perfusion with SPECT/CT with the advantage of higher temporal and spatial resolution. • The hyperpolarized xenon-129 MRI correlates with the PFT measurements better than the high-resolution CT with the advantage of avoiding the use of ionizing radiation.

Dataset Information

Complementary regional heterogeneity information from COPD patients obtained using oxygen-enhanced MRI and chest CT.

Background

Methods

Results

Conclusions

Publications

Complementary regional heterogeneity information from COPD patients obtained using oxygen-enhanced MRI and chest CT.

Similar Datasets

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