Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI.
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ABSTRACT:
SUBMITTER: Harrison IF
PROVIDER: S-EPMC6117153 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI.
Harrison Ian F IF Siow Bernard B Akilo Aisha B AB Evans Phoebe G PG Ismail Ozama O Ohene Yolanda Y Nahavandi Payam P Thomas David L DL Lythgoe Mark F MF Wells Jack A JA
eLife 20180731
The glymphatics system describes a CSF-mediated clearance pathway for the removal of potentially harmful molecules, such as amyloid beta, from the brain. As such, its components may represent new therapeutic targets to alleviate aberrant protein accumulation that defines the most prevalent neurodegenerative conditions. Currently, however, the absence of any non-invasive measurement technique prohibits detailed understanding of glymphatic function in the human brain and in turn, it's role in path ...[more]
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