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Dynamics of virus-specific T cell immunity in pediatric liver transplant recipients.


ABSTRACT: Immunosuppression following solid organ transplantation (SOT) has a deleterious effect on cellular immunity leading to frequent and prolonged viral infections. To better understand the relationship between posttransplant immunosuppression and circulating virus-specific T cells, we prospectively monitored the frequency and function of T cells directed to a range of latent (CMV, EBV, HHV6, BK) and lytic (AdV) viruses in 16 children undergoing liver transplantation for up to 1 year posttransplant. Following transplant, there was an immediate decline in circulating virus-specific T cells, which recovered posttransplant, coincident with the introduction and subsequent routine tapering of immunosuppression. Furthermore, 12 of 14 infections/reactivations that occurred posttransplant were successfully controlled with immunosuppression reduction (and/or antiviral use) and in all cases we detected a temporal increase in the circulating frequency of virus-specific T cells directed against the infecting virus, which was absent in 2 cases where infections remained uncontrolled by the end of follow-up. Our study illustrates the dynamic changes in virus-specific T cells that occur in children following liver transplantation, driven both by active viral replication and modulation of immunosuppression.

SUBMITTER: Arasaratnam RJ 

PROVIDER: S-EPMC6117219 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Dynamics of virus-specific T cell immunity in pediatric liver transplant recipients.

Arasaratnam R J RJ   Tzannou I I   Gray T T   Aguayo-Hiraldo P I PI   Kuvalekar M M   Naik S S   Gaikwad A A   Liu H H   Miloh T T   Vera J F JF   Himes R W RW   Munoz F M FM   Leen A M AM  

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20180710 9


Immunosuppression following solid organ transplantation (SOT) has a deleterious effect on cellular immunity leading to frequent and prolonged viral infections. To better understand the relationship between posttransplant immunosuppression and circulating virus-specific T cells, we prospectively monitored the frequency and function of T cells directed to a range of latent (CMV, EBV, HHV6, BK) and lytic (AdV) viruses in 16 children undergoing liver transplantation for up to 1 year posttransplant.  ...[more]

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