Ontology highlight
ABSTRACT:
SUBMITTER: Iezaki T
PROVIDER: S-EPMC6117477 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Iezaki Takashi T Horie Tetsuhiro T Fukasawa Kazuya K Kitabatake Makoto M Nakamura Yuka Y Park Gyujin G Onishi Yuki Y Ozaki Kakeru K Kanayama Takashi T Hiraiwa Manami M Kitaguchi Yuka Y Kaneda Katsuyuki K Manabe Takayuki T Ishigaki Yasuhito Y Ohno Mutsuhito M Hinoi Eiichi E
Stem cell reports 20180628 1
The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs/SOX9 axis in regulating skeletogenesis through its expression in undifferentiated mesenchymal cells. Inactivation of Raptor, a component of mTORC1, in limb buds before mesenchymal condensations resulted in a marked loss of both cartilage and bone. Mechanisti ...[more]