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Oral probenecid improves sperm motility in men with spinal cord injury.

ABSTRACT: STUDY DESIGN:Prospective cohort study (twenty men with spinal cord injury [SCI]). OBJECTIVE:Determine if administration of oral probenecid results in improved sperm motility in men with SCI. SETTING:Major university medical center. METHODS:Twenty men with SCI were administered probenecid for 4 weeks (250?mg twice a day for 1 week, followed by 500?mg twice a day for 3 weeks). Semen quality was assessed at three time points: pre-treatment, post-treatment (immediately after the 4-week treatment), and follow-up (4 weeks after the last pill was ingested). RESULT(S):Probenecid was well-tolerated by all subjects. Sperm motility improved in each subject after 4 weeks of oral probenecid. The mean percent of sperm with progressive motility increased from 19% to 26% (P < 0.05). A more striking increase was seen in the mean percent of sperm with rapid linear motility, from 5% to 17%, (P <0.001). This improvement continued into the four week follow up period. Similar improvements were seen in the total motile sperm count (15 million, 28 million, and 27 million at pre-treatment, post-treatment, and follow-up, respectively). Sperm concentration was not significantly different at pre-treatment, post-treatment, and follow-up, (52 million, 53 million and 53 million, respectively). CONCLUSION:This study showed that administration of an oral agent (probenecid) known to interfere with the pannexin-1 cellular membrane channel, can improve sperm motility in men with spinal cord injury. It is the first study to report improved sperm motility after oral medication in men with SCI.

SUBMITTER: Ibrahim E

PROVIDER: S-EPMC6117571 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Oral probenecid improves sperm motility in men with spinal cord injury.

Ibrahim Emad E Aballa Teodoro C TC Lynne Charles M CM Brackett Nancy L NL

The journal of spinal cord medicine 20170502 5

<h4>Study design</h4>Prospective cohort study (twenty men with spinal cord injury [SCI]).<h4>Objective</h4>Determine if administration of oral probenecid results in improved sperm motility in men with SCI.<h4>Setting</h4>Major university medical center.<h4>Methods</h4>Twenty men with SCI were administered probenecid for 4 weeks (250 mg twice a day for 1 week, followed by 500 mg twice a day for 3 weeks). Semen quality was assessed at three time points: pre-treatment, post-treatment (immediately a ...[more]

PMID: 28464732

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Project description:Spinal cord injury (SCI) is usually a sudden traumatic event and has a negative effect on sexual function.To evaluate the characteristics of sexual activity in men with SCI and identify predictors of being sexually active and having a satisfactory sex life.We assessed sexual activity profiles of men with SCI from a Brazilian tertiary rehabilitation center from February to August 2012. All patients older than 18 years with SCI for longer than 1 year were invited to participate. We analyzed age, time since SCI, patient age at SCI, employment status, partner status, completeness of lesion, functional independence, urinary continence, and Sexual Health Inventory for Men (SHIM) score.The SHIM was used to assess erectile function (EF). Satisfaction with sex life was analyzed as a dichotomous variable. Predictors of an active and satisfactory sex life were identified using univariable and multivariable analyses.We evaluated 295 men with mean age of 40.7 ± 14.5 years. Most patients had a complete SCI (65.1%) and 159 (53.9%) were incontinent. The median SHIM score was 5 (interquartile range = 0-16) and only 71 men (24.1%) had a SHIM score of at least 17. Of these men, 159 (53.9%) were sexually active. Only 63 men (39.6%) were satisfied with their sex life after SCI. In univariable analysis, all variables were associated with an active sex life. Those with a SHIM score of at least 17 had a greater likelihood of being sexually active (odds ratio = 116, 95% confidence interval = 14-432). EF was the only parameter associated with a satisfactory sex life (odds ratio = 1.3, 95% confidence interval = 1.2-1.4).Most men with SCI were sexually inactive and/or dissatisfied with their sex life. Age, duration of SCI, completeness of SCI, continence, having a partner, and good EF were identified as predictors of an active sex life. However, only EF was a predictor of a satisfactory sex life. Gomes CM, Miranda EP, de Bessa J, et al. Erectile Function Predicts Sexual Satisfaction in Men With Spinal Cord Injury. Sex Med 2017;5:e148-e155.

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Oral probenecid improves sperm motility in men with spinal cord injury.

Publications

Oral probenecid improves sperm motility in men with spinal cord injury.

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