Eutypellenoids A?C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1.

ABSTRACT: Three new pimarane diterpenes, eutypellenoids A?C (1?3), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 1?3 possessed an uncommon tetrahydrofuran-fused pimarane diterpene skeleton. The structures of all compounds were determined by detailed spectroscopic analysis, electronic circular dichroism (ECD) analysis, as well as a comparison with the literature data. Antibacterial, antifungal, and cytotoxic activities of these compounds were evaluated. Compound 2 displayed antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 8 and 8 ?g/mL, respectively. Additionally, compound 2 showed antifungal activity against Candidaparapsilosis, Candida albicans, Candida glabrata, and Candida tropicalis with MIC values of 8, 8, 16, and 32 ?g/mL, respectively. Furthermore, compound 2 exhibited moderate cytotoxic activity against HCT-116 cell line with IC50 value of 3.7 ?M.

SUBMITTER: Yu HB 

PROVIDER: S-EPMC6117666 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature