Ontology highlight
ABSTRACT:
SUBMITTER: Anders KL
PROVIDER: S-EPMC6118074 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Anders Katherine L KL Cutcher Zoe Z Kleinschmidt Immo I Donnelly Christl A CA Ferguson Neil M NM Indriani Citra C Ryan Peter A PA O'Neill Scott L SL Jewell Nicholas P NP Simmons Cameron P CP
American journal of epidemiology 20180901 9
Cluster-randomized controlled trials are the gold standard for assessing efficacy of community-level interventions, such as vector-control strategies against dengue. We describe a novel cluster-randomized trial methodology with a test-negative design (CR-TND), which offers advantages over traditional approaches. This method uses outcome-based sampling of patients presenting with a syndrome consistent with the disease of interest, who are subsequently classified as test-positive cases or test-neg ...[more]