Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC6118232 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Chen Wei W Yi Jin Kyu JK Shimane Tetsu T Mehrazarin Shebli S Lin Yi-Ling YL Shin Ki-Hyuk KH Kim Reuben H RH Park No-Hee NH Kang Mo K MK
Carcinogenesis 20160301 5
Grainyhead-like 2 (GRHL2) is one of the three mammalian homologues of Drosophila Grainyhead involved in epithelial morphogenesis. We recently showed that GRHL2 also controls normal epithelial cell proliferation and differentiation. In this study, we investigated the role of GRHL2 in oral carcinogenesis and the underlying mechanism. GRHL2 expression was elevated in cells and tissues of oral squamous cell carcinomas (OSCCs) compared with normal counterparts. Knockdown of GRHL2 resulted in the loss ...[more]