Ontology highlight
ABSTRACT:
SUBMITTER: Dolan WL
PROVIDER: S-EPMC6118316 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Dolan Whitney L WL Chapple Clint C
G3 (Bethesda, Md.) 20180830 9
The Mediator complex is a central component of transcriptional regulation in Eukaryotes. The complex is structurally divided into four modules known as the head, middle, tail and kinase modules, and in <i>Arabidopsis thaliana</i>, comprises 28-34 subunits. Here, we explore the functions of four Arabidopsis Mediator tail subunits, MED2, MED5a/b, MED16, and MED23, by comparing the impact of mutations in each on the Arabidopsis transcriptome. We find that these subunits affect both unique and overl ...[more]