Ontology highlight
ABSTRACT:
SUBMITTER: Jakubec D
PROVIDER: S-EPMC6118372 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Jakubec David D Kratochvíl Miroslav M Vymĕtal Jiří J Vondrášek Jiří J
PloS one 20180831 8
Domains are distinct units within proteins that typically can fold independently into recognizable three-dimensional structures to facilitate their functions. The structural and functional independence of protein domains is reflected by their apparent modularity in the context of multi-domain proteins. In this work, we examined the coupling of evolution of domain sequences co-occurring within multi-domain proteins to see if it proceeds independently, or in a coordinated manner. We used continuou ...[more]