Ontology highlight
ABSTRACT:
SUBMITTER: Rizzolio S
PROVIDER: S-EPMC6118581 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Rizzolio Sabrina S Cagnoni Gabriella G Battistini Chiara C Bonelli Stefano S Isella Claudio C Van Ginderachter Jo A JA Bernards René R Di Nicolantonio Federica F Giordano Silvia S Tamagnone Luca L
The Journal of clinical investigation 20180813 9
Cancer cell dependence on activated oncogenes is therapeutically targeted, but acquired resistance is virtually unavoidable. Here we show that the treatment of addicted melanoma cells with BRAF inhibitors, and of breast cancer cells with HER2-targeted drugs, led to an adaptive rise in neuropilin-1 (NRP1) expression, which is crucial for the onset of acquired resistance to therapy. Moreover, NRP1 levels dictated the efficacy of MET oncogene inhibitors in addicted stomach and lung carcinoma cells. ...[more]