TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence.
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ABSTRACT:
SUBMITTER: Puig I
PROVIDER: S-EPMC6118637 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence.
Puig Isabel I Tenbaum Stephan P SP Chicote Irene I Arqués Oriol O Martínez-Quintanilla Jordi J Cuesta-Borrás Estefania E Ramírez Lorena L Gonzalo Pilar P Soto Atenea A Aguilar Susana S Eguizabal Cristina C Caratù Ginevra G Prat Aleix A Argilés Guillem G Landolfi Stefania S Casanovas Oriol O Serra Violeta V Villanueva Alberto A Arroyo Alicia G AG Terracciano Luigi L Nuciforo Paolo P Seoane Joan J Recio Juan A JA Vivancos Ana A Dienstmann Rodrigo R Tabernero Josep J Palmer Héctor G HG
The Journal of clinical investigation 20180806 9
Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. We have adapted the pulse-chase expression of H2BeGFP for labeling and isolating slow-cycling cancer cells (SCCCs). SCCCs showed cancer initiation potential and enhanced chemoresistance. Cells at this slow-cycling status presented a distinctive nongenetic and cell-autonomous gene expression profile shared across different tumor t ...[more]
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